2.9M XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Erick J. Lucera | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 1.71 per share. | 04 Mar 2025 | 4,109 | 112,720 (0%) | 0% | 1.7 | 7,030 | Common Stock |
| Linda Burkly | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 1.71 per share. | 04 Mar 2025 | 2,891 | 70,245 (0%) | 0% | 1.7 | 4,946 | Common Stock |
| Mei Baisong | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 2.08 per share. | 03 Dec 2024 | 541 | 133,354 (0%) | 0% | 2.1 | 1,124 | Common Stock |
| Baisong Mei | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 3.42 per share. | 04 Sep 2024 | 518 | 133,895 (0%) | 0% | 3.4 | 1,774 | Common Stock |
| Linda Burkly | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 5.42 per share. | 25 Jul 2024 | 11,886 | 73,136 (0%) | 0% | 5.4 | 64,370 | Common Stock |
| Baisong Mei | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 5.21 per share. | 19 Jul 2024 | 6,619 | 134,413 (0%) | 0% | 5.2 | 34,456 | Common Stock |
| Baisong Mei | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 5.50 per share. | 04 Jun 2024 | 511 | 141,032 (0%) | 0% | 5.5 | 2,808 | Common Stock |
| Akshay K. Vaishnaw | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Andrew J. Hirsch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Jessica Hopfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Emma Reeve | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| David T. Scadden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Bernadette M. Connaughton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Meeta Chatterjee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Elliott M. Levy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Erick J. Lucera | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 5.61 per share. | 20 May 2024 | 22,337 | 116,829 (0%) | 0% | 5.6 | 125,404 | Common Stock |
| Jessica Hopfield | Director | Purchase of securities on an exchange or from another person at price $ 5.64 per share. | 13 May 2024 | 45,000 | 67,700 (0%) | 0% | 5.6 | 253,868 | Common Stock |
| Erick J. Lucera | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 106,000 | 106,000 | - | - | Stock Option (right to buy) | |
| Erick J. Lucera | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 25,966 | 139,166 (0%) | 0% | 0 | Common Stock | |
| Erick J. Lucera | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 35,300 | 113,200 (0%) | 0% | 0 | Common Stock | |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 9.42 per share. | 02 Mar 2024 | 20,327 | 141,543 (0%) | 0% | 9.4 | 191,425 | Common Stock |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 152,800 | 152,800 | - | - | Stock Option (right to buy) | |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 50,900 | 122,955 (0%) | 0% | 0 | Common Stock | |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 19,458 | 142,413 (0%) | 0% | 0 | Common Stock | |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 19,457 | 161,870 (0%) | 0% | 0 | Common Stock | |
| Linda Burkly | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 74,400 | 74,400 | - | - | Stock Option (right to buy) | |
| Linda Burkly | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 15,055 | 85,022 (0%) | 0% | 0 | Common Stock | |
| Linda Burkly | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2024 | 24,800 | 69,967 (0%) | 0% | 0 | Common Stock | |
| Eaton Bruce | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 10.89 per share. | 05 Dec 2023 | 103 | 74,791 (0%) | 0% | 10.9 | 1,122 | Common Stock |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 8.59 per share. | 11 Aug 2023 | 702 | 75,831 (0%) | 0% | 8.6 | 6,033 | Common Stock |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 8.39 per share. | 08 Aug 2023 | 141 | 76,533 (0%) | 0% | 8.4 | 1,183 | Common Stock |
| Linda Burkly | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2023 | 135,500 | 135,500 | - | - | Stock Option (right to buy) | |
| Linda Burkly | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2023 | 45,167 | 45,167 (0%) | 0% | 0 | Common Stock | |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 8.80 per share. | 19 Jul 2023 | 4,317 | 72,055 (0%) | 0% | 8.8 | 37,990 | Common Stock |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 9.50 per share. | 05 Jun 2023 | 105 | 76,674 (0%) | 0% | 9.5 | 998 | Common Stock |
| Akshay K. Vaishnaw | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Andrew J. Hirsch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Jessica Hopfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Emma Reeve | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| David T. Scadden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Bernadette M. Connaughton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Meeta Chatterjee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Erick J. Lucera | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 155,800 | 155,800 | - | - | Stock Option (right to buy) | |
| Erick J. Lucera | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 77,900 | 77,900 (0%) | 0% | 0 | Common Stock | |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 9.87 per share. | 11 May 2023 | 949 | 106,610 (0%) | 0% | 9.9 | 9,369 | Common Stock |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 9.87 per share. | 11 May 2023 | 668 | 76,779 (0%) | 0% | 9.9 | 6,594 | Common Stock |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 9.51 per share. | 09 May 2023 | 135 | 77,447 (0%) | 0% | 9.5 | 1,284 | Common Stock |
| Elliott M. Levy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Apr 2023 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 31,500 | 107,743 (0%) | 0% | 0 | Common Stock | |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 8.89 per share. | 02 Mar 2023 | 184 | 107,559 (0%) | 0% | 8.9 | 1,636 | Common Stock |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 94,500 | 94,500 | - | - | Stock Option (right to buy) | |
| Bruce Eaton | EVP, CBO AND CTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 16,700 | 77,683 (0%) | 0% | 0 | Common Stock | |
| Bruce Eaton | EVP, CBO AND CTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 8.89 per share. | 02 Mar 2023 | 101 | 77,582 (0%) | 0% | 8.9 | 898 | Common Stock |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 18,000 | 76,372 (0%) | 0% | 0 | Common Stock | |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 54,000 | 54,000 | - | - | Stock Option (right to buy) | |
| Mark S. Shearman | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 9.67 per share. | 13 Feb 2023 | 2,790 | 65,559 (0%) | 0% | 9.7 | 26,966 | Common Stock |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 9.67 per share. | 13 Feb 2023 | 4,287 | 76,243 (0%) | 0% | 9.7 | 41,435 | Common Stock |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 9.67 per share. | 13 Feb 2023 | 3,307 | 60,983 (0%) | 0% | 9.7 | 31,963 | Common Stock |
| Bruce Eaton | EVP, CBO AND CTO | Sale of securities on an exchange or to another person at price $ 11.10 per share. | 07 Feb 2023 | 346 | 64,290 (0%) | 0% | 11.1 | 3,841 | Common Stock |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 8.16 per share. | 10 Jan 2023 | 1,752 | 80,530 (0%) | 0% | 8.2 | 14,296 | Common Stock |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 10.23 per share. | 05 Dec 2022 | 193 | 82,282 (0%) | 0% | 10.2 | 1,974 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 10.23 per share. | 05 Dec 2022 | 102 | 64,636 (0%) | 0% | 10.2 | 1,043 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 11.02 per share. | 08 Nov 2022 | 289 | 64,738 (0%) | 0% | 11.0 | 3,185 | Common Stock |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 15.01 per share. | 06 Sep 2022 | 192 | 82,475 (0%) | 0% | 15.0 | 2,882 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 15.01 per share. | 06 Sep 2022 | 101 | 65,027 (0%) | 0% | 15.0 | 1,516 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 18.60 per share. | 09 Aug 2022 | 293 | 65,128 (0%) | 0% | 18.6 | 5,449 | Common Stock |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2022 | 171,602 | 171,602 | - | - | Stock Option (right to buy) | |
| Baisong Mei | SVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jul 2022 | 58,372 | 58,372 (0%) | 0% | 0 | Common Stock | |
| Mark S. Shearman | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 10.06 per share. | 15 Jun 2022 | 5,145 | 68,349 (0%) | 0% | 10.1 | 51,745 | Common Stock |
| Akshay K. Vaishnaw | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Andrew J. Hirsch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Jessica Hopfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Emma Reeve | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| David T. Scadden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Bernadette M. Connaughton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Meeta Chatterjee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 11.54 per share. | 03 Jun 2022 | 1,527 | 82,667 (0%) | 0% | 11.5 | 17,617 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 11.54 per share. | 03 Jun 2022 | 1,123 | 65,421 (0%) | 0% | 11.5 | 12,956 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 13.11 per share. | 09 May 2022 | 297 | 66,544 (0%) | 0% | 13.1 | 3,895 | Common Stock |
| James C. Mullen | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 170,989 | 170,989 | - | - | Stock Option (right to buy) | |
| Michelle Robertson | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 17.33 per share. | 03 Mar 2022 | 767 | 84,194 (0%) | 0% | 17.3 | 13,290 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 17.33 per share. | 03 Mar 2022 | 403 | 68,386 (0%) | 0% | 17.3 | 6,983 | Common Stock |
| Bruce Eaton | EVP, CHIEF BUSINESS OFFICER | Sale of securities on an exchange or to another person at price $ 17.63 per share. | 08 Feb 2022 | 302 | 31,196 (0%) | 0% | 17.6 | 5,323 | Common Stock |
| Michelle Robertson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.70 per share. | 11 Jan 2022 | 1,744 | 31,462 (0%) | 0% | 25.7 | 44,821 | Common Stock |
| James C. Mullen | Director, CEO | Sale of securities on an exchange or to another person at price $ 26.95 per share. | 03 Jan 2022 | 18,252 | 75,898 (0%) | 0% | 27.0 | 491,979 | Common Stock |
| James C. Mullen | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2021 | 36,477 | 94,150 (0%) | 0% | 0 | Common Stock | |
| Michelle Robertson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2021 | 4,471 | 33,206 (0%) | 0% | 0 | Common Stock | |
| Lisa Anne Michaels | EVP/Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2021 | 4,243 | 22,675 (0%) | 0% | 0 | Common Stock | |
| Bruce Eaton | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2021 | 3,472 | 31,498 (0%) | 0% | 0 | Common Stock | |
| Lisa Anne Michaels | EVP/Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 38.33 per share. | 12 Nov 2021 | 1,568 | 18,432 (0%) | 0% | 38.3 | 60,101 | Common Stock |
| Bruce Eaton | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 40.61 per share. | 09 Nov 2021 | 287 | 28,026 (0%) | 0% | 40.6 | 11,655 | Common Stock |
| Bernadette M. Connaughton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Oct 2021 | 24,732 | 24,732 | - | - | Stock Option (right to buy) | |
| James C. Mullen | Director, CEO | Sale of securities on an exchange or to another person at price $ 38.03 per share. | 18 Oct 2021 | 13,805 | 57,673 (0%) | 0% | 38.0 | 525,033 | Common Stock |
| James C. Mullen | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 36,478 | 71,478 (0%) | 0% | 0 | Common Stock | |
| Emma Reeve | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2021 | 13,736 | 13,736 | - | - | Stock Option (right to buy) | |
| Michelle Robertson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.65 per share. | 09 Aug 2021 | 2,500 | 31,235 (0%) | 0% | 30.7 | 76,625 | Common Stock |
| Michelle Robertson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2021 | 2,500 | 115,000 | - | - | Stock Option (right to buy) | |
| Michelle Robertson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 09 Aug 2021 | 2,500 | 28,735 (0%) | 0% | 60 | 150,000 | Common Stock |
| Michelle Robertson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2021 | 2,500 | 117,500 | - | - | Stock Option (right to buy) | |
| Michelle Robertson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 28 Jun 2021 | 2,500 | 28,735 (0%) | 0% | 50 | 125,000 | Common Stock |
| Michelle Robertson | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.65 per share. | 28 Jun 2021 | 2,500 | 31,235 (0%) | 0% | 30.7 | 76,625 | Common Stock |
| Akshay K. Vaishnaw | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2021 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Andrew Hirsch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2021 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Jessica Hopfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2021 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| David T. Scadden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2021 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Meeta Chatterjee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2021 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Jessica Hopfield | Director | Purchase of securities on an exchange or from another person at price $ 45.51 per share. | 03 Mar 2021 | 5,800 | 22,700 (0%) | 0% | 45.5 | 263,970 | Common Stock |
| James C. Mullen | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 196,637 | 196,637 | - | - | Stock Option (right to buy) | |
| James C. Mullen | Director, CEO | Purchase of securities on an exchange or from another person at price $ 46.27 per share. | 02 Mar 2021 | 25,000 | 35,000 (0%) | 0% | 46.3 | 1,156,800 | Common Stock |
| Michelle Robertson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 10,303 | 28,735 (0%) | 0% | 0 | Common Stock | |
| Michelle Robertson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2021 | 32,197 | 32,197 | - | - | Stock Option (right to buy) | |
| Cynthia Collins | CEO | Sale of securities on an exchange or to another person at price $ 66.65 per share. | 09 Feb 2021 | 1,262 | 43,760 (0%) | 0% | 66.6 | 84,112 | Common Stock |
| Michelle Robertson | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 78.27 per share. | 12 Jan 2021 | 1,568 | 18,432 (0%) | 0% | 78.3 | 122,727 | Common Stock |
| Meeta Chatterjee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2020 | 23,076 | 23,076 | - | - | Stock Option (right to buy) | |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2020 | 10,000 | 145,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 64.39 per share. | 15 Dec 2020 | 200 | 24,907 (0%) | 0% | 64.4 | 12,878 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 63.84 per share. | 15 Dec 2020 | 4,024 | 25,107 (0%) | 0% | 63.8 | 256,892 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 62.74 per share. | 15 Dec 2020 | 5,776 | 29,131 (0%) | 0% | 62.7 | 362,386 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.51 per share. | 15 Dec 2020 | 10,000 | 34,907 (0%) | 0% | 16.5 | 165,100 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.51 per share. | 09 Dec 2020 | 10,000 | 34,907 (0%) | 0% | 16.5 | 165,100 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2020 | 10,000 | 155,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 09 Dec 2020 | 10,000 | 24,907 (0%) | 0% | 45 | 450,000 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 40.02 per share. | 07 Dec 2020 | 20,000 | 24,907 (0%) | 0% | 40.0 | 800,400 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2020 | 20,000 | 165,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.51 per share. | 07 Dec 2020 | 20,000 | 44,907 (0%) | 0% | 16.5 | 330,200 | Common Stock |
| Lisa Anne Michaels | EVP/Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Nov 2020 | 120,000 | 120,000 | - | - | Stock Option (right to buy) | |
| Lisa Anne Michaels | EVP/Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Nov 2020 | 20,000 | 20,000 (0%) | 0% | 0 | Common Stock | |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.39 per share. | 15 Oct 2020 | 3,000 | 25,135 (0%) | 0% | 31.4 | 94,170 | Common Stock |
| Cynthia Collins | Director, CEO | Sale of securities on an exchange or to another person at price $ 36.66 per share. | 20 Aug 2020 | 1,976 | 45,022 (0%) | 0% | 36.7 | 72,440 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.51 per share. | 17 Aug 2020 | 10,000 | 38,135 (0%) | 0% | 16.5 | 165,100 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.29 per share. | 17 Aug 2020 | 10,000 | 28,135 (0%) | 0% | 35.3 | 352,900 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 10,000 | 185,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2020 | 10,000 | 195,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | EVP/Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.51 per share. | 06 Aug 2020 | 10,000 | 38,373 (0%) | 0% | 16.5 | 165,100 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 37.47 per share. | 06 Aug 2020 | 10,000 | 28,373 (0%) | 0% | 37.5 | 374,700 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 34.99 per share. | 06 Aug 2020 | 238 | 28,135 (0%) | 0% | 35.0 | 8,328 | Common Stock |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.22 per share. | 15 Jul 2020 | 3,000 | 28,373 (0%) | 0% | 32.2 | 96,660 | Common Stock |
| James C. Mullen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2020 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Akshay K. Vaishnaw | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2020 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Andrew Hirsch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2020 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Jessica Hopfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2020 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| David Scadden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2020 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Charles Albright | EVP/Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 25.28 per share. | 06 May 2020 | 151 | 31,373 (0%) | 0% | 25.3 | 3,817 | Common Stock |
| Cynthia Collins | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 93,750 | 93,750 | - | - | Stock Option (right to buy) | |
| Cynthia Collins | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 15,625 | 46,998 (0%) | 0% | 0 | Common Stock | |
| Charles Albright | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 26.95 per share. | 06 Feb 2020 | 622 | 31,524 (0%) | 0% | 27.0 | 16,763 | Common Stock |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 11,593 | 32,146 (0%) | 0% | 0 | Common Stock | |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2020 | 69,556 | 69,556 | - | - | Stock Option (right to buy) | |
| Charles Albright | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 26.54 per share. | 31 Jan 2020 | 5,549 | 20,553 (0%) | 0% | 26.5 | 147,288 | Common Stock |
| Charles Albright | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2020 | 17,977 | 0 | - | - | Restricted Stock Units | |
| Charles Albright | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2020 | 17,977 | 26,102 (0%) | 0% | 0 | Common Stock | |
| Michelle Robertson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2020 | 20,000 | 20,000 (0%) | 0% | 0 | Common Stock | |
| Michelle Robertson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jan 2020 | 120,000 | 120,000 | - | - | Stock Option (right to buy) | |
| Judith Abrams | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Oct 2019 | 150,000 | 150,000 | - | - | Stock Option (right to buy) | |
| Judith Abrams | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Oct 2019 | 25,000 | 25,000 (0%) | 0% | 0 | Common Stock | |
| Cynthia Collins | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2019 | 20,000 | 31,373 (0%) | 0% | 0 | Common Stock | |
| Cynthia Collins | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2019 | 250,000 | 250,000 | - | - | Stock Option (right to buy) | |
| Cynthia Collins | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2019 | 500,000 | 500,000 | - | - | Stock Option (right to buy) | |
| Cynthia Collins | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Aug 2019 | 8,283 | 16,566 (0%) | 0% | 0 | Common Stock | |
| Cynthia Collins | Director, CEO | Sale of securities on an exchange or to another person at price $ 25.83 per share. | 19 Aug 2019 | 5,193 | 11,373 (0%) | 0% | 25.8 | 134,135 | Common Stock |
| Cynthia Collins | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2019 | 8,283 | 16,566 (0%) | 0% | 0 | Common Stock | |
| Cynthia Collins | Director, Interim CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2019 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| James C. Mullen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2019 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Akshay K. Vaishnaw | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2019 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Andrew Hirsch | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2019 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Jessica Hopfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2019 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 24.50 per share. | 18 Mar 2019 | 3,000 | 0 (0%) | 0% | 24.5 | 73,500 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2019 | 3,000 | 73,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 18 Mar 2019 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Jessica Hopfield | None | Purchase of securities on an exchange or from another person at price $ 23.94 per share. | 05 Mar 2019 | 10,200 | 16,900 (0%) | 0% | 23.9 | 244,188 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 20 Feb 2019 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 20.42 per share. | 20 Feb 2019 | 3,000 | 0 (0%) | 0% | 20.4 | 61,260 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Feb 2019 | 3,000 | 76,307 | - | - | Stock Option (right to buy) | |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 8,125 | 8,125 | - | - | Restricted Stock Units | |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 48,750 | 48,750 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 8,125 | 8,125 | - | - | Restricted Stock Units | |
| Vickesh Myer | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 48,750 | 48,750 | - | - | Stock Option (right to buy) | |
| David Scadden | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 23,076 | 23,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.39 per share. | 04 Feb 2019 | 6,895 | 0 (0%) | 0% | 21.4 | 147,484 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2019 | 6,895 | 9,618 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 04 Feb 2019 | 6,895 | 6,895 (0%) | 0% | 6.5 | 44,680 | Common Stock |
| Cynthia Collins | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2019 | 8,283 | 8,283 | - | - | Restricted Stock Units | |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2019 | 17,977 | 17,977 | - | - | Restricted Stock Units | |
| Vickesh Myer | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2019 | 16,722 | 16,722 | - | - | Restricted Stock Units | |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 26.50 per share. | 17 Jan 2019 | 4,000 | 0 (0%) | 0% | 26.5 | 106,000 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2019 | 4,000 | 52,897 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2019 | 3,000 | 79,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 17 Jan 2019 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Jan 2019 | 4,000 | 4,000 (0%) | 0% | 11.2 | 44,840 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 26.18 per share. | 17 Jan 2019 | 3,000 | 0 (0%) | 0% | 26.2 | 78,540 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.27 per share. | 08 Jan 2019 | 12,000 | 1,204,966 (2%) | 0% | 25.3 | 303,240 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2019 | 7,000 | 16,513 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.48 per share. | 04 Jan 2019 | 7,000 | 0 (0%) | 0% | 22.5 | 157,360 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 04 Jan 2019 | 7,000 | 7,000 (0%) | 0% | 6.5 | 45,360 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 27.41 per share. | 17 Dec 2018 | 4,000 | 0 (0%) | 0% | 27.4 | 109,640 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Dec 2018 | 4,000 | 4,000 (0%) | 0% | 11.2 | 44,840 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2018 | 3,000 | 82,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2018 | 4,000 | 56,897 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 17 Dec 2018 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 27.75 per share. | 17 Dec 2018 | 2,300 | 700 (0%) | 0% | 27.8 | 63,825 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 28.34 per share. | 17 Dec 2018 | 700 | 0 (0%) | 0% | 28.3 | 19,838 | Common Stock |
| Cynthia Collins | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2018 | 23,076 | 23,076 | - | - | Stock Option (right to buy) | |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.92 per share. | 03 Dec 2018 | 11,900 | 1,217,066 (2%) | 0% | 31.9 | 379,848 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.39 per share. | 03 Dec 2018 | 100 | 1,216,966 (2%) | 0% | 32.4 | 3,239 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 23 Nov 2018 | 5,284 | 5,284 (0%) | 0% | 3.2 | 17,067 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2018 | 5,284 | 119,143 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 26.50 per share. | 19 Nov 2018 | 4,000 | 0 (0%) | 0% | 26.5 | 106,000 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 19 Nov 2018 | 4,000 | 4,000 (0%) | 0% | 11.2 | 44,840 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 28.85 per share. | 19 Nov 2018 | 300 | 0 (0%) | 0% | 28.9 | 8,655 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 19 Nov 2018 | 300 | 300 (0%) | 0% | 0.7 | 195 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 19 Nov 2018 | 2,700 | 2,700 (0%) | 0% | 0.7 | 1,755 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 19 Nov 2018 | 2,700 | 0 (0%) | 0% | 28.1 | 75,924 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2018 | 3,000 | 85,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2018 | 4,000 | 60,897 | - | - | Stock Option (right to buy) | |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 27.21 per share. | 01 Nov 2018 | 8,600 | 1,228,966 (2%) | 0% | 27.2 | 234,006 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 26.03 per share. | 01 Nov 2018 | 3,400 | 1,237,566 (2%) | 0% | 26.0 | 88,502 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 26 Oct 2018 | 6,000 | 6,000 (0%) | 0% | 3.2 | 19,380 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Oct 2018 | 6,000 | 124,427 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2018 | 3,000 | 88,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 29.44 per share. | 17 Oct 2018 | 4,000 | 0 (0%) | 0% | 29.4 | 117,760 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 28.87 per share. | 17 Oct 2018 | 3,000 | 0 (0%) | 0% | 28.9 | 86,610 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Oct 2018 | 4,000 | 4,000 (0%) | 0% | 11.2 | 44,840 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2018 | 4,000 | 64,897 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 17 Oct 2018 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 30.64 per share. | 01 Oct 2018 | 6,234 | 1,246,732 (2%) | 0% | 30.6 | 191,010 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.44 per share. | 01 Oct 2018 | 5,766 | 1,240,966 (2%) | 0% | 31.4 | 181,283 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2018 | 8,000 | 23,513 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 32.08 per share. | 28 Sep 2018 | 8,000 | 0 (0%) | 0% | 32.1 | 256,640 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 28 Sep 2018 | 8,000 | 8,000 (0%) | 0% | 6.5 | 51,840 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 17 Sep 2018 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 32.19 per share. | 17 Sep 2018 | 4,000 | 0 (0%) | 0% | 32.2 | 128,760 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Sep 2018 | 4,000 | 4,000 (0%) | 0% | 11.2 | 44,840 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 32.33 per share. | 17 Sep 2018 | 3,000 | 0 (0%) | 0% | 32.3 | 96,990 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2018 | 3,000 | 91,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2018 | 4,000 | 68,897 | - | - | Stock Option (right to buy) | |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.27 per share. | 04 Sep 2018 | 10,787 | 1,254,179 (2%) | 0% | 32.3 | 348,096 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 33.07 per share. | 04 Sep 2018 | 1,213 | 1,252,966 (2%) | 0% | 33.1 | 40,114 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2018 | 10,000 | 31,513 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 32.23 per share. | 31 Aug 2018 | 10,000 | 0 (0%) | 0% | 32.2 | 322,300 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 31 Aug 2018 | 10,000 | 10,000 (0%) | 0% | 6.5 | 64,800 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 30.43 per share. | 20 Aug 2018 | 5,433 | 1,264,966 (2%) | 0% | 30.4 | 165,326 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 29.95 per share. | 20 Aug 2018 | 6,567 | 1,270,399 (2%) | 0% | 30.0 | 196,682 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Aug 2018 | 3,600 | 3,600 (0%) | 0% | 11.2 | 40,356 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 17 Aug 2018 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2018 | 3,000 | 94,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2018 | 4,000 | 72,897 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 29.81 per share. | 17 Aug 2018 | 3,600 | 0 (0%) | 0% | 29.8 | 107,316 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 29.65 per share. | 17 Aug 2018 | 3,000 | 0 (0%) | 0% | 29.7 | 88,950 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 30.41 per share. | 17 Aug 2018 | 400 | 0 (0%) | 0% | 30.4 | 12,164 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Aug 2018 | 400 | 400 (0%) | 0% | 11.2 | 4,484 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 29.36 per share. | 01 Aug 2018 | 6,233 | 1,279,066 (2%) | 0% | 29.4 | 183,001 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 30.12 per share. | 01 Aug 2018 | 2,100 | 1,276,966 (2%) | 0% | 30.1 | 63,252 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2018 | 7,000 | 97,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 34.66 per share. | 17 Jul 2018 | 3,000 | 0 (0%) | 0% | 34.7 | 103,980 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 17 Jul 2018 | 3,000 | 3,000 (0%) | 0% | 0.7 | 1,950 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 17 Jul 2018 | 4,000 | 4,000 (0%) | 0% | 0.7 | 2,600 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2018 | 7,000 | 76,897 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 36.25 per share. | 17 Jul 2018 | 850 | 0 (0%) | 0% | 36.3 | 30,813 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Jul 2018 | 850 | 850 (0%) | 0% | 11.2 | 9,529 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 35.46 per share. | 17 Jul 2018 | 6,150 | 0 (0%) | 0% | 35.5 | 218,079 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 17 Jul 2018 | 6,150 | 6,150 (0%) | 0% | 11.2 | 68,942 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 36.50 per share. | 17 Jul 2018 | 4,000 | 0 (0%) | 0% | 36.5 | 146,000 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 36.00 per share. | 02 Jul 2018 | 3,000 | 1,290,632 (2%) | 0% | 36 | 108,000 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 36.46 per share. | 02 Jul 2018 | 5,333 | 1,285,299 (2%) | 0% | 36.5 | 194,441 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jun 2018 | 7,000 | 83,897 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jun 2018 | 7,000 | 104,307 | - | - | Stock Option (right to buy) | |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 18 Jun 2018 | 4,300 | 4,300 (0%) | 0% | 0.7 | 2,795 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 37.75 per share. | 18 Jun 2018 | 4,300 | 0 (0%) | 0% | 37.8 | 162,325 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 18 Jun 2018 | 2,700 | 2,700 (0%) | 0% | 0.7 | 1,755 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 38.71 per share. | 18 Jun 2018 | 2,700 | 0 (0%) | 0% | 38.7 | 104,517 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.21 per share. | 18 Jun 2018 | 7,000 | 7,000 (0%) | 0% | 11.2 | 78,470 | Common Stock |
| Vickesh Myer | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 38.39 per share. | 18 Jun 2018 | 7,000 | 0 (0%) | 0% | 38.4 | 268,730 | Common Stock |
| Akshay K. Vaishnaw | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2018 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Andrew Hirsch | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2018 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Boris Nikolic | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2018 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Charles Albright | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.98 per share. | 13 Jun 2018 | 10,000 | 0 (0%) | 0% | 36.0 | 359,800 | Common Stock |
| Charles Albright | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jun 2018 | 10,000 | 205,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.51 per share. | 13 Jun 2018 | 10,000 | 10,000 (0%) | 0% | 16.5 | 165,100 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 37.18 per share. | 01 Jun 2018 | 6,214 | 1,295,751 (2%) | 0% | 37.2 | 231,037 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 39.15 per share. | 01 Jun 2018 | 800 | 1,293,932 (2%) | 0% | 39.2 | 31,320 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 37.81 per share. | 01 Jun 2018 | 1,019 | 1,294,732 (2%) | 0% | 37.8 | 38,528 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 39.96 per share. | 01 Jun 2018 | 300 | 1,293,632 (2%) | 0% | 40.0 | 11,988 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2018 | 7,000 | 41,513 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2018 | 3,000 | 67,500 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 01 Jun 2018 | 5,000 | 5,000 (0%) | 0% | 6.5 | 32,400 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 39.05 per share. | 01 Jun 2018 | 5,000 | 0 (0%) | 0% | 39.1 | 195,250 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 01 Jun 2018 | 2,000 | 2,000 (0%) | 0% | 6.5 | 12,960 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 39.86 per share. | 01 Jun 2018 | 2,000 | 0 (0%) | 0% | 39.9 | 79,720 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.60 per share. | 01 Jun 2018 | 3,000 | 3,000 (0%) | 0% | 24.6 | 73,800 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 37.10 per share. | 01 Jun 2018 | 3,000 | 0 (0%) | 0% | 37.1 | 111,300 | Common Stock |
| Charles Albright | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 23 May 2018 | 10,000 | 0 (0%) | 0% | 35 | 350,000 | Common Stock |
| Charles Albright | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.51 per share. | 23 May 2018 | 10,000 | 10,000 (0%) | 0% | 16.5 | 165,100 | Common Stock |
| Charles Albright | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2018 | 10,000 | 215,000 | - | - | Stock Option (right to buy) | |
| James C. Mullen | None | Purchase of securities on an exchange or from another person at price $ 38.03 per share. | 18 May 2018 | 10,000 | 10,000 (0%) | 0% | 38.0 | 380,252 | Common Stock |
| Jessica Hopfield | None | Purchase of securities on an exchange or from another person at price $ 37.28 per share. | 17 May 2018 | 6,700 | 6,700 (0%) | 0% | 37.3 | 249,780 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.95 per share. | 01 May 2018 | 8,333 | 1,301,965 (2%) | 0% | 31.9 | 266,239 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.83 per share. | 02 Apr 2018 | 4,833 | 1,313,798 (2%) | 0% | 31.8 | 153,834 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.61 per share. | 02 Apr 2018 | 3,500 | 1,310,298 (2%) | 0% | 32.6 | 114,135 | Common Stock |
| James C. Mullen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Mar 2018 | 23,076 | 23,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 37.65 per share. | 16 Mar 2018 | 6,000 | 0 (0%) | 0% | 37.7 | 225,900 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 37.51 per share. | 16 Mar 2018 | 5,000 | 0 (0%) | 0% | 37.5 | 187,550 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 16 Mar 2018 | 1,000 | 1,000 (0%) | 0% | 6.5 | 6,480 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 38.39 per share. | 16 Mar 2018 | 1,000 | 0 (0%) | 0% | 38.4 | 38,390 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.60 per share. | 16 Mar 2018 | 22,000 | 22,000 (0%) | 0% | 24.6 | 541,200 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 37.91 per share. | 16 Mar 2018 | 22,000 | 0 (0%) | 0% | 37.9 | 834,020 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2018 | 22,000 | 70,500 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2018 | 6,000 | 48,513 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2018 | 6,000 | 54,513 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2018 | 6,000 | 60,513 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 16 Mar 2018 | 6,000 | 6,000 (0%) | 0% | 6.5 | 38,880 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 39.43 per share. | 16 Mar 2018 | 6,000 | 0 (0%) | 0% | 39.4 | 236,580 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 16 Mar 2018 | 6,000 | 6,000 (0%) | 0% | 6.5 | 38,880 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 16 Mar 2018 | 5,000 | 5,000 (0%) | 0% | 6.5 | 32,400 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 09 Mar 2018 | 9,134 | 1,318,631 (2%) | 0% | 45 | 411,030 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.87 per share. | 01 Mar 2018 | 4,800 | 1,329,565 (2%) | 0% | 35.9 | 172,176 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.61 per share. | 01 Mar 2018 | 1,733 | 1,334,365 (2%) | 0% | 34.6 | 59,979 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 36.41 per share. | 01 Mar 2018 | 1,800 | 1,327,765 (2%) | 0% | 36.4 | 65,538 | Common Stock |
| Jessica Hopfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2018 | 23,076 | 23,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 14 Feb 2018 | 6,000 | 6,000 (0%) | 0% | 6.5 | 38,880 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 34.61 per share. | 14 Feb 2018 | 6,000 | 0 (0%) | 0% | 34.6 | 207,660 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 14 Feb 2018 | 6,000 | 6,000 (0%) | 0% | 6.5 | 38,880 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 35.32 per share. | 14 Feb 2018 | 6,000 | 0 (0%) | 0% | 35.3 | 211,920 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2018 | 6,000 | 69,662 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 32.71 per share. | 14 Feb 2018 | 6,000 | 0 (0%) | 0% | 32.7 | 196,260 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2018 | 6,000 | 63,662 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2018 | 6,000 | 75,662 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.48 per share. | 14 Feb 2018 | 6,000 | 6,000 (0%) | 0% | 6.5 | 38,880 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2018 | 275,000 | 275,000 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2018 | 95,000 | 95,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2018 | 71,500 | 71,500 | - | - | Stock Option (right to buy) | |
| Gerald Frank Cox | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2018 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.79 per share. | 01 Feb 2018 | 5,533 | 1,338,898 (2%) | 0% | 35.8 | 198,032 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 36.71 per share. | 01 Feb 2018 | 2,100 | 1,336,798 (2%) | 0% | 36.7 | 77,097 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 37.60 per share. | 01 Feb 2018 | 700 | 1,336,098 (2%) | 0% | 37.6 | 26,322 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 37.53 per share. | 29 Jan 2018 | 10,000 | 1,354,431 (2%) | 0% | 37.5 | 375,340 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 40.05 per share. | 29 Jan 2018 | 10,000 | 1,344,431 (2%) | 0% | 40.1 | 400,520 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.28 per share. | 23 Jan 2018 | 3,338 | 1,364,431 (3%) | 0% | 35.3 | 117,765 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.01 per share. | 02 Jan 2018 | 1,703 | 1,380,561 (3%) | 0% | 32.0 | 54,510 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 33.63 per share. | 02 Jan 2018 | 2,193 | 1,378,368 (3%) | 0% | 33.6 | 73,759 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.23 per share. | 02 Jan 2018 | 3,937 | 1,374,431 (3%) | 0% | 34.2 | 134,744 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.04 per share. | 02 Jan 2018 | 6,662 | 1,367,769 (3%) | 0% | 35.0 | 233,416 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.25 per share. | 02 Jan 2018 | 500 | 1,382,264 (3%) | 0% | 31.2 | 15,624 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2017 | 4,649 | 130,427 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2017 | 5,000 | 140,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 15 Dec 2017 | 4,649 | 4,649 (0%) | 0% | 3.2 | 15,016 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.68 per share. | 15 Dec 2017 | 5,000 | 0 (0%) | 0% | 24.7 | 123,409 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 15 Dec 2017 | 5,000 | 5,000 (0%) | 0% | 3.2 | 16,150 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.31 per share. | 15 Dec 2017 | 5,000 | 0 (0%) | 0% | 24.3 | 121,546 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 15 Dec 2017 | 5,000 | 5,000 (0%) | 0% | 3.2 | 16,150 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.06 per share. | 15 Dec 2017 | 4,649 | 0 (0%) | 0% | 25.1 | 116,510 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2017 | 5,000 | 135,076 | - | - | Stock Option (right to buy) | |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 29.87 per share. | 01 Dec 2017 | 5,133 | 1,382,764 (3%) | 0% | 29.9 | 153,348 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 29.12 per share. | 01 Dec 2017 | 3,200 | 1,387,897 (3%) | 0% | 29.1 | 93,174 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.81 per share. | 17 Nov 2017 | 5,000 | 0 (0%) | 0% | 24.8 | 124,073 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 17 Nov 2017 | 5,000 | 5,000 (0%) | 0% | 3.2 | 16,150 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Nov 2017 | 5,000 | 150,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Nov 2017 | 5,000 | 145,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.35 per share. | 17 Nov 2017 | 5,000 | 0 (0%) | 0% | 25.3 | 126,732 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 17 Nov 2017 | 5,000 | 5,000 (0%) | 0% | 3.2 | 16,150 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 23.37 per share. | 01 Nov 2017 | 6,108 | 1,393,322 (3%) | 0% | 23.4 | 142,773 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.05 per share. | 01 Nov 2017 | 300 | 1,391,097 (3%) | 0% | 25.0 | 7,514 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 24.25 per share. | 01 Nov 2017 | 1,925 | 1,391,397 (3%) | 0% | 24.2 | 46,679 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.33 per share. | 02 Oct 2017 | 200 | 1,399,430 (3%) | 0% | 25.3 | 5,066 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 24.77 per share. | 02 Oct 2017 | 8,133 | 1,399,630 (3%) | 0% | 24.8 | 201,459 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.40 per share. | 01 Sep 2017 | 9,800 | 1,414,629 (3%) | 0% | 20.4 | 199,911 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.20 per share. | 01 Sep 2017 | 6,666 | 1,407,763 (3%) | 0% | 20.2 | 134,681 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 21.20 per share. | 01 Sep 2017 | 200 | 1,414,429 (3%) | 0% | 21.2 | 4,239 | Common Stock |
| Douglas G. Cole | None | Other type of transaction at price $ 0.00 per share. | 17 Aug 2017 | 1,686 | 3,171 (0%) | 0% | 0 | Common Stock | |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.02 per share. | 10 Aug 2017 | 10,000 | 1,431,095 (3%) | 0% | 20.0 | 200,160 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.02 per share. | 10 Aug 2017 | 6,666 | 1,424,429 (3%) | 0% | 20.0 | 133,450 | Common Stock |
| Alexis A. Borisy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| John D. Mendlein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Akshay K. Vaishnaw | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Douglas G. Cole | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Kevin Bitterman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Boris Nikolic | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 11,538 | 11,538 | - | - | Stock Option (right to buy) | |
| Boris Nikolic | None | Purchase of securities on an exchange or from another person at price $ 14.07 per share. | 02 Jun 2017 | 35,000 | 35,000 (0%) | 0% | 14.1 | 492,527 | Common Stock |
| Gerald Frank Cox | Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 14.15 per share. | 02 Jun 2017 | 4,000 | 4,000 (0%) | 0% | 14.2 | 56,600 | Common Stock |
| Andrew Hirsch | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2017 | 23,076 | 23,076 | - | - | Stock Option (right to buy) | |
| Kevin Bitterman | None | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 22 May 2017 | 1,000,000 | 2,797,144 (6%) | 2% | 17 | 17,000,000 | Common Stock |
| Alexandra Glucksmann | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 26.41 per share. | 15 Mar 2017 | 1,000 | 117,788 (0%) | 0% | 26.4 | 26,410 | Common Stock |
| Alexandra Glucksmann | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2017 | 1,000 | 30,461 | - | - | Stock Option (right to buy) | |
| Alexandra Glucksmann | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 15 Mar 2017 | 1,000 | 118,788 (0%) | 0% | 0.7 | 650 | Common Stock |
| Katrine S. Bosley | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2017 | 312,000 | 312,000 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2017 | 92,500 | 92,500 | - | - | Stock Option (right to buy) | |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2017 | 45,000 | 45,000 | - | - | Stock Option (right to buy) | |
| Alexandra Glucksmann | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 15 Feb 2017 | 6,000 | 123,788 (0%) | 0% | 0.7 | 3,900 | Common Stock |
| Alexandra Glucksmann | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 15 Feb 2017 | 5,000 | 118,788 (0%) | 0% | 20 | 100,000 | Common Stock |
| Alexandra Glucksmann | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 23.48 per share. | 15 Feb 2017 | 1,000 | 117,788 (0%) | 0% | 23.5 | 23,484 | Common Stock |
| Alexandra Glucksmann | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Feb 2017 | 6,000 | 31,461 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Feb 2017 | 3,000 | 155,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.20 per share. | 15 Feb 2017 | 3,000 | 0 (0%) | 0% | 19.2 | 57,600 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 15 Feb 2017 | 3,000 | 3,000 (0%) | 0% | 3.2 | 9,690 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2017 | 15,000 | 158,076 | - | - | Stock Option (right to buy) | |
| Andrew A. F. Hack | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.23 per share. | 11 Jan 2017 | 15,000 | 15,000 (0%) | 0% | 3.2 | 48,450 | Common Stock |
| Andrew A. F. Hack | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.20 per share. | 11 Jan 2017 | 15,000 | 0 (0%) | 0% | 19.2 | 288,000 | Common Stock |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Dec 2016 | 75,000 | 3,797,144 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Dec 2016 | 80,000 | 3,922,144 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Dec 2016 | 50,000 | 3,872,144 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Nov 2016 | 21,480 | 4,002,144 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 22 Nov 2016 | 12,819 | 4,023,624 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Nov 2016 | 30,830 | 4,036,443 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Nov 2016 | 498 | 4,067,273 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Nov 2016 | 30,367 | 4,067,771 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Nov 2016 | 58,035 | 4,098,138 | - | - | Common Stock | |
| Gerald Frank Cox | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Oct 2016 | 225,000 | 225,000 | - | - | Stock Option (right to buy) | |
| Charles Albright | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2016 | 225,000 | 225,000 | - | - | Stock Option (right to buy) | |
| Kevin Bitterman | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 08 Sep 2016 | 500,000 | 4,156,173 | - | - | Common Stock | |
| Kevin P. Starr | Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 06 Sep 2016 | 5,890 | 0 | - | - | Common Stock | |
| Alexandra Glucksmann | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2016 | 1,000 | 37,461 | - | - | Stock Option (right to buy) | |
| Alexandra Glucksmann | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Aug 2016 | 1,000 | 117,788 | - | - | Common Stock | |
| Alexandra Glucksmann | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2016 | 1,000 | 118,788 | - | - | Common Stock | |
| Mark J. Levin | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Aug 2016 | 750,000 | 3,906,176 | - | - | Common Stock | |
| Noubar B. Afeyan | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 11 Aug 2016 | 50,271 | 0 | - | - | Common Stock | |
| Noubar B. Afeyan | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 11 Aug 2016 | 1,200,000 | 2,764,256 | - | - | Common Stock | |
| Noubar B. Afeyan | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 11 Aug 2016 | 300,000 | 691,060 | - | - | Common Stock | |
| Douglas G. Cole | None | Other type of transaction at price $ 0.00 per share. | 11 Aug 2016 | 1,485 | 1,485 | - | - | Common Stock | |
| Akshay K. Vaishnaw | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2016 | 23,076 | 23,076 | - | - | Stock Option (right to buy) | |
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 1,325,708 | 0 | - | - | Series A-1 Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 1,617,015 | 3,656,564 | - | - | Common Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 76,922 | 991,060 | - | - | Common Stock | ||
| Mark J. Levin | Ten Percent Owner | 08 Feb 2016 | 4,656,176 | 4,656,176 | - | - | Common Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 800,001 | 0 | - | - | Series B Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 2,039,549 | 2,039,549 | - | - | Common Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 404,253 | 914,138 | - | - | Common Stock | ||
| Mark J. Levin | Ten Percent Owner | 08 Feb 2016 | 222,222 | 0 | - | - | Series B Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 4,204,240 | 0 | - | - | Series A-2 Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 199,999 | 0 | - | - | Series B Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 509,885 | 509,885 | - | - | Common Stock | ||
| Mark J. Levin | Ten Percent Owner | 08 Feb 2016 | 5,255,300 | 0 | - | - | Series A-2 Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 5,302,834 | 0 | - | - | Series A-1 Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 1,051,060 | 0 | - | - | Series A-2 Preferred Stock | ||
| Noubar B. Afeyan | Ten Percent Owner | 08 Feb 2016 | 307,692 | 3,964,256 | - | - | Common Stock | ||
| Mark J. Levin | Ten Percent Owner | 08 Feb 2016 | 6,628,542 | 0 | - | - | Series A-1 Preferred Stock | ||
| Flynn E James | Other | 08 Feb 2016 | 854,700 | 854,700 | - | - | Common Stock | ||
| Flynn E James | Other | 08 Feb 2016 | 854,700 | 854,700 | - | - | Common Stock | ||
| Flynn E James | Other | 08 Feb 2016 | 854,700 | 0 | - | - | Series B Preferred Stock | ||
| Flynn E James | Other | 08 Feb 2016 | 854,700 | 0 | - | - | Series B Preferred Stock | ||
| Flynn E James | Other | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 08 Feb 2016 | 100,000 | 954,700 | - | - | Common Stock | |
| Kevin Bitterman | Director, Ten Percent Owner | 08 Feb 2016 | 6,628,542 | 0 | - | - | Series A-1 Preferred Stock | ||
| Kevin Bitterman | Director, Ten Percent Owner | 08 Feb 2016 | 2,021,269 | 4,570,704 | - | - | Common Stock | ||
| Kevin Bitterman | Director, Ten Percent Owner | 08 Feb 2016 | 5,255,300 | 0 | - | - | Series A-2 Preferred Stock | ||
| Kevin Bitterman | Director, Ten Percent Owner | 08 Feb 2016 | 85,469 | 4,656,173 | - | - | Common Stock | ||
| Kevin Bitterman | Director, Ten Percent Owner | 08 Feb 2016 | 222,222 | 0 | - | - | Series B Preferred Stock | ||
| Kevin Bitterman | Director, Ten Percent Owner | 08 Feb 2016 | 2,549,435 | 2,549,435 | - | - | Common Stock | ||
| Katrine S. Bosley | Director, President and CEO | 08 Feb 2016 | 11,111 | 0 | - | - | Series B Preferred Stock | ||
| Katrine S. Bosley | Director, President and CEO | 08 Feb 2016 | 192,027 | 0 | - | - | Series A-2 Preferred Stock | ||
| Katrine S. Bosley | Director, President and CEO | 08 Feb 2016 | 4,273 | 1,441,095 | - | - | Common Stock | ||
| Katrine S. Bosley | Director, President and CEO | 08 Feb 2016 | 73,856 | 1,436,822 | - | - | Common Stock | ||
| Boris Nikolic | None | 08 Feb 2016 | 6,888,888 | 0 | - | - | Series B Preferred Stock | ||
| Boris Nikolic | None | 08 Feb 2016 | 2,649,572 | 2,649,572 | - | - | Common Stock | ||
| John D. Mendlein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2016 | 96,153 | 96,153 | - | - | Stock Option (right to buy) | |
| Katrine S. Bosley | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2016 | 38,461 | 38,461 | - | - | Stock Option (right to buy) |